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Elevated LHRH levels in human milk.

R M Nair, A K Sarda, M A Barnes

    Endocrinologia Experimentalis
    |October 1, 1983
    PubMed
    Summary
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    Human milk contains significantly higher levels of luteinizing hormone-releasing hormone (LHRH) than plasma. This discovery suggests potential extrahypothalamic origins and important functions for LHRH in neonates.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Neonatal Physiology

    Background:

    • Anterior pituitary gonadotropins are primarily regulated by hypothalamic LHRH.
    • Evidence suggests LHRH has extrahypothalamic sources and extrapituitary actions.
    • The role of LHRH in neonatal development warrants further investigation.

    Purpose of the Study:

    • To investigate the presence and levels of LHRH in human milk.
    • To explore the potential origin and biological significance of LHRH in milk for neonates.

    Main Methods:

    • Collected simultaneous blood and human milk samples from lactating mothers.
    • Developed specialized extraction and concentration techniques for milk and plasma LHRH.
    • Quantified LHRH levels using a sensitive double antibody radioimmunoassay with 125I-LHRH.

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    Main Results:

    • Human milk exhibited 5-6 times higher LHRH concentrations compared to plasma samples.
    • Purified milk LHRH demonstrated full in vivo biological activity.
    • Thyrotropin-releasing hormone (TRH) was found in much lower concentrations in milk, unlike LHRH.

    Conclusions:

    • Elevated LHRH in human milk is likely of extrahypothalamic origin, not solely from hypothalamic release.
    • High levels of LHRH in milk may play a crucial role in neonatal biological processes.
    • This finding extends the understanding of LHRH's influence beyond the pituitary, potentially impacting neonatal development following intrauterine exposure.