[Histogenesis and morphology of the tissues of the rabbit ear chamber--current light and electron microscopy...

The freshly inserted rabbit ear chamber is filled with blood. During the first few days, a fibrin network develops that is deposited mainly on the cover slip and base plate. Fibroblasts from the surrounding tissue invade the chamber migrating on this fibrin scaffold. They change from a rod-like shape into completely flattened cells that produce the connective tissue fibers, and then become hardly recognizable. Centripetal blood vessel sprouting can be observed at the periphery after about 2 weeks. The initial overproduction of vessels is followed by a massive reduction and differentiation. The complete mature vascular system lying between two connective tissue sheets needs about 6--8 weeks to develop. Lymphatics occasionally arise in the same manner, and fat cells occur in individual chambers. The connective tissue is superficially coated with a layer of flattened cells. Aside from other cells (mainly mononuclears). Multinucleated giant cells are found on the cover slip and base plate of the chambers.