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Related Experiment Videos

Orally administered grass pollen.

E Taudorf, B Weeke

    Allergy
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Oral administration of enteric-coated grass pollen tablets was evaluated for hay fever treatment. This safety study found no adverse effects or significant changes in allergic reactivity, suggesting potential safety for oral immunotherapy.

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    Area of Science:

    • Allergy and Immunology
    • Clinical Pharmacology
    • Gastroenterology

    Background:

    • Oral administration of ragweed for hay fever hyposensitization was proposed in 1900.
    • Previous studies on oral hyposensitization have yielded mixed results, with only one controlled trial showing no effect.
    • High doses of oral pollen have not been extensively studied for safety and efficacy.

    Purpose of the Study:

    • To determine the safety and effectiveness of orally administered enteric-coated grass pollen tablets in patients with hay fever.
    • To evaluate the safety of a significantly higher dose of grass pollen than typically recommended for oral hyposensitization.
    • To assess changes in allergic reactivity and immunological markers following treatment.

    Main Methods:

    • A double-blind, randomized controlled trial involving twelve young adults with grass pollen hay fever.

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  • Participants were allocated to receive enteric-coated Conjuvac Timothy tablets, Whole Timothy pollen tablets, or placebo tablets.
  • Patients received high doses of pollen preseasonally and over six months, with safety and allergic responses monitored.

    • Main Results:

    • No side effects were reported in patients receiving active treatment with enteric-coated grass pollen tablets.
    • No significant changes were observed in skin prick test reactivity or nasal provocation tests.
    • No significant alterations were found in timothy-specific IgE, IgG, total IgE, or histamine release from basophils.

    Conclusions:

    • Orally administered enteric-coated grass pollen tablets appear to be safe at the tested high doses.
    • The study did not demonstrate significant changes in allergic reactivity or immunological markers, warranting further investigation into efficacy.
    • Further controlled trials are needed to establish the effectiveness of this oral immunotherapy approach for hay fever.