Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic prophylaxis in neurosurgery. A randomized controlled trial.

J Geraghty, M Feely

    Journal of Neurosurgery
    |April 1, 1984
    PubMed
    Summary

    Prophylactic antibiotics significantly reduced neurosurgical wound infections. This study found a 0.5% infection rate in treated patients compared to 3.5% in controls, demonstrating antibiotic effectiveness.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Invasive lobular carcinoma of the breast; clinicopathologic profile and response to neoadjuvant chemotherapy over a 15-year period.

    Breast (Edinburgh, Scotland)·2024
    Same author

    Letter to the Editor: Recognizing patient harm through inclusive study recruitment.

    Journal of advanced nursing·2024
    Same author

    The association between breast density and breast cancer pathological response to neoadjuvant chemotherapy.

    Breast cancer research and treatment·2022
    Same author

    Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2022
    Same author

    Value of a 21-gene expression assay on core biopsy to predict neoadjuvant chemotherapy response in breast cancer: systematic review and meta-analysis.

    The British journal of surgery·2021
    Same author

    The approach to an isolated close anterior margin in breast conserving surgery.

    Annals of the Royal College of Surgeons of England·2019

    Area of Science:

    • Neurosurgery
    • Infectious Disease Prevention
    • Clinical Trials

    Background:

    • Postoperative neurosurgical wound infections pose a significant risk.
    • Reducing infection rates is crucial for patient outcomes.
    • Standard prophylactic measures are continuously evaluated.

    Purpose of the Study:

    • To evaluate the efficacy of prophylactic antibiotics in preventing neurosurgical wound infections.
    • To compare infection rates between a treated group and a control group.

    Main Methods:

    • A randomized trial was conducted following the Malis regimen.
    • Patients received systemic vancomycin and gentamicin pre-surgery.
    • Streptomycin was added to the surgical irrigating solution for the treated group.
    • Patients were randomly assigned to either a control or a treated group.

    Main Results:

    • The control group experienced an infection rate of 3.5%.
    • The treated group, receiving prophylactic antibiotics, had a significantly lower infection rate of 0.5%.

    Conclusions:

    • Prophylactic antibiotic administration is effective in reducing the incidence of postoperative neurosurgical wound infections.
    • The specific antibiotic regimen used demonstrated a substantial decrease in infection rates.
    • This supports the routine use of targeted prophylactic antibiotics in neurosurgical procedures.

    Related Experiment Videos