Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Urea Cycle

Urea Cycle

The urea cycle describes how liver cells convert ammonia to urea. Ammonia is a toxic waste product of protein catabolism. Land animals must convert ammonia into the less toxic urea which can be safely eliminated by the kidneys through urine. Marine animals excrete ammonia directly, and the surrounding water dilutes the ammonia to safe levels.

Aneurysm IV: Nursing Management

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...

Urinary Tract Calculi V: Nursing Management

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...

Urinary Tract Calculi VI: Surgical Management

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Hepatic Encephalopathy

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Structures and electron attachment properties of halomethanes (CX(n)Y(m), X=H, F; Y=Cl, Br, I; n=0,4; m=4-n).

SAR and QSAR in environmental research·2001

Same author

Zeeman-Stark modeling of the RF EMF interaction with ligand binding.

Bioelectromagnetics·2000

Same author

Relationship between plain radiographic patterns and three- dimensional trabecular architecture in the human calcaneus.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·1999

Same author

Computational methods for ultrasonic bone assessment.

Ultrasound in medicine & biology·1999

Same author

Acoustic assessment of fracture healing. Capabilities and limitations of "a lost art".

American journal of orthopedics (Belle Mead, N.J.)·1996

Same author

Influence of marrow on ultrasonic velocity and attenuation in bovine trabecular bone.

Calcified tissue international·1996

Search research articles

Related Experiment Video

Updated: Jul 22, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Ammoniagenic coma following ureterosigmoidostomy.

The Journal of Urology

|April 1, 1984

Summary

Ammoniagenic coma, a rare ureterosigmoidostomy complication, can occur even with normal liver function. This case highlights that normal liver ornithine-urea cycle synthesis typically prevents such episodes.

Area of Science:

Nephrology
Gastroenterology
Biochemistry

Background:

Ureterosigmoidostomy is a surgical procedure that reroutes ureters to the sigmoid colon.
Ammoniagenic coma is a rare but serious complication associated with this procedure.
This condition involves elevated ammonia levels leading to neurological impairment.

Observation:

A case of ammoniagenic coma following ureterosigmoidostomy is presented.
The patient exhibited unusual features, including normal liver function tests.
Liver biopsy also revealed normal histology, which is atypical for such cases.

Findings:

The patient's normal liver function and biopsy suggest preserved hepatic metabolic capacity.
Despite the coma, the ornithine-urea cycle in the liver appeared to be functioning normally.

More Related Videos

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jul 22, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

This challenges the typical understanding of the pathophysiology of ammoniagenic coma.

Implications:

This case suggests that ammoniagenic coma may arise from mechanisms beyond impaired hepatic urea synthesis.
Further investigation into extrahepatic ammonia metabolism or shunt pathways is warranted.
Understanding these alternative pathways could lead to improved diagnostic and therapeutic strategies for patients with ureterosigmoidostomy.