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[Cortical hyperostoses after long-term prostaglandin E2 therapy].

G Benz-Bohm, D Emons, S Schickendantz

|February 1, 1984

Summary

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Prostaglandin therapy in infants can cause cortical hyperostoses, a condition resembling Caffey's disease. Higher dosages and longer treatment durations appear to increase this risk.

Area of Science:

Pediatric medicine
Pharmacology
Radiology

Background:

Cortical hyperostoses are a known side effect of prostaglandin E1 and E2 therapy in infants.
These hyperostoses are radiologically indistinguishable from Caffey's disease.
The pathogenesis of prostaglandin-induced hyperostoses and its relation to Caffey's disease warrant investigation.

Purpose of the Study:

To investigate the occurrence of cortical hyperostoses in infants treated with prostaglandin E2 for ductal-related heart defects.
To explore the correlation between prostaglandin dosage, duration of therapy, and the development of hyperostoses.
To discuss the potential pathogenetic relationship between prostaglandin-induced hyperostoses and Caffey's disease.

Main Methods:

Retrospective analysis of 62 cases of newborn infants.

Related Experiment Videos

Infants received prostaglandin E2 for ductal-related vitium cordis.

Evaluation of treatment duration and dosage.

Main Results:

Cortical hyperostoses were observed as a side effect in infants treated with prostaglandin E1 and E2.
A correlation was noted between the dosage and duration of prostaglandin therapy and the incidence of hyperostoses.
Radiological findings of these lesions were similar to those of Caffey's disease.

Conclusions:

Prostaglandin therapy in early infancy is associated with cortical hyperostoses.
The risk of developing hyperostoses appears dose- and duration-dependent.
Further research is needed to elucidate the pathogenetic link between prostaglandin-induced hyperostoses and Caffey's disease.