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Atherogenic risk in obese and in diabetic children
Insights
Childhood obesity and diabetes mellitus present significant atherogenic risks. Early intervention is crucial for preventing atherosclerosis, as factors like abnormal insulin, lipid, and cortisol levels are involved.
Area of Science:
- Pediatrics
- Endocrinology
- Pathology
Background:
- Obesity and diabetes mellitus are prevalent childhood conditions.
- Atherosclerosis is a significant health concern with early origins.
- The atherogenic risk factors in these conditions require further elucidation.
Purpose of the Study:
- To investigate the atherogenic risk factors associated with childhood obesity and diabetes mellitus.
- To explore the roles of biochemical, immunologic, and ultrastructural changes in atherogenesis.
- To establish the necessity of early prophylactic measures against atherosclerosis.
Main Methods:
- Complex biochemical, immunologic, morphohistochemical, and ultrastructural analyses were performed.
- A study group comprised 42 obese children and 38 diabetic children.
- A control group of 12 normal children was included for comparison.
Main Results:
- Obesity and diabetes mellitus were confirmed as significant atherogenic risk factors.
- Abnormal insulinemia, lipidemia, and cortisolemia were implicated in the atherogenesis process.
- Immunologic factors, microangiopathy (in diabetes), and capillary lesions (in obesity) were identified as contributing risks.
Conclusions:
- Atherogenesis is multifactorial, involving metabolic and immunologic pathways.
- Early detection and management of obesity and diabetes are vital for cardiovascular health.
- Childhood represents a critical window for atherosclerosis prophylaxis.
Abstract:
By a complex biochemical, immunologic, morphohistochemical and ultrastructural study, carried out on a group of 42 obese and 38 diabetic children, comparatively with 12 normal controls, the authors arrive at conclusions which prove that obesity and diabetes mellitus carry great atherogenic risk factors. Even though the intimate atherogenesis mechanism is not perfectly known, the abnormal values of insulinemia, lipidemia and cortisolemia are certainly involved in this process. In diabetes mellitus the immunologic factor is also involved. Microangiopathy in diabetes mellitus and capillary lesions in the adipose tissue of obese children may also represent atherogenic risk factors. An efficient prophylaxis in atherosclerosis must therefore begin in childhood.