Serotypic variation of culture-adapted isolates of P. falciparum

Culture adapted isolates of P. falciparum had different growth patterns (P less than 0.01) when cultured in the presence of sera obtained from 31 healthy Papua New Guinea residents. Both enhancement and suppression of growth was observed. Less variation was observed using an indirect immunofluorescent antibody method directed against schizont antigens, and no correlation between the two assays was found. This bioassay is assessed as a basis for serotyping P. falciparum strains.