Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal pathology associated with lithium therapy.

R G Walker, J P Dowling, D Alcorn

    Pathology
    |October 1, 1983
    PubMed
    Summary

    Lithium therapy for severe affective disorders can cause a distinct kidney lesion in the tubules and collecting ducts, characterized by glycogen accumulation. This finding was observed in patients currently on lithium but not in those who stopped treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cash Transfers may Increase the No-show Rate for Surgical Patients in Low-resource Settings: A Randomized Controlled Trial.

    West African journal of medicine·2022
    Same author

    Design of microresonators to minimize thermal noise below the standard quantum limit.

    The Review of scientific instruments·2020
    Same author

    Toward Scalable Boson Sampling with Photon Loss.

    Physical review letters·2018
    Same author

    An unusual onset of agminated Spitz naevi in an adult patient.

    Clinical and experimental dermatology·2017
    Same author

    Environmental stress in the Gulf of Mexico and its potential impact on public health.

    Environmental research·2016
    Same author

    Cogito, ergo thumb.

    Anaesthesia·2013

    Area of Science:

    • Nephrology
    • Psychiatry
    • Cell Biology

    Background:

    • Lithium is a common treatment for severe affective disorders.
    • Long-term lithium use has been associated with renal abnormalities.
    • The specific renal pathology induced by lithium requires further characterization.

    Purpose of the Study:

    • To investigate the renal histopathological changes associated with lithium therapy.
    • To identify specific lesions in patients on maintenance lithium.
    • To determine the temporal relationship between lithium treatment and observed renal changes.

    Main Methods:

    • Renal biopsies from patients on maintenance lithium therapy (n=50) and previously on lithium (n=5) were examined.
    • Light and ultrastructural techniques were used to analyze cellular and tissue morphology.

    Related Experiment Videos

  • Prospective studies monitored renal changes after commencing lithium treatment.

    • Main Results:

    • A distinctive lesion was identified in the distal convoluted tubules and collecting ducts of patients currently on lithium.
    • This lesion featured cytoplasmic vacuolation, swelling, and accumulation of PAS-positive material, confirmed as particulate glycogen.
    • The 'lithium-associated' lesion was absent in patients who had discontinued lithium therapy.
    • Glycogen accumulation was observed within days of starting lithium treatment.

    Conclusions:

    • Maintenance lithium therapy induces a specific renal lesion characterized by glycogen accumulation in the distal tubules and collecting ducts.
    • This lesion is directly associated with active lithium treatment.
    • The clinical significance and relationship of this lesion to interstitial fibrosis warrant further investigation.