Dynamic CT in the evaluation of physiologic status of renal transplants

Dynamic computed tomographic scans were performed in 23 patients to evaluate perfusion and function of renal transplants. Using corticomedullary junction and corticoarterial junction attenuation/time curve analysis, we were able to differentiate normal renal transplants from those undergoing rejection. Corticomedullary junction time was used to assess function and was significant in distinguishing normal renal transplants from those with rejection (p less than 0.001). Similarly, corticoarterial junction time was used to assess perfusion and had a significance of p less than 0.05. The study demonstrates the ability of computed tomography to yield excellent physiologic information.