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Related Experiment Videos

Immunologic cross-reactivity between Streptococcus mutans and mammalian tissues.

R J Nisengard, M W Stinson, L Pelonero

    Annals of the New York Academy of Sciences
    |January 1, 1983
    PubMed
    Summary

    Oral streptococci share antigens with human tissues. Some Streptococcus mutans strains showed cross-reactivity with cardiac and skeletal muscle, and kidney tissues, suggesting potential autoimmune implications.

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    Area of Science:

    • Immunology
    • Microbiology
    • Biochemistry

    Background:

    • Oral streptococci, including Streptococcus mutans, are common bacteria.
    • Autoimmune responses can be triggered by shared antigens between microbes and host tissues.
    • Understanding cross-reactivity is crucial for studying host-microbe interactions.

    Purpose of the Study:

    • To investigate shared antigens between oral streptococci and human/primate tissues.
    • To identify specific Streptococcus mutans serotypes and strains that exhibit cross-reactivity.
    • To explore the potential autoimmune implications of these cross-reactions.

    Main Methods:

    • Indirect immunofluorescence was used to detect antigen cross-reactivity.
    • Rabbit antisera against seven serotypes of Streptococcus mutans were employed.

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  • Tissues examined included cardiac muscle, skeletal muscle, kidney, brain, liver, and skin.

    • Main Results:

    • Antisera to S. mutans serotype g (strain OMZ-65) reacted with cardiac muscle, reducible by bacterial cell membranes.
    • Antisera to S. mutans serotype g (strain K-1) reacted with cardiac and skeletal muscle, not reducible by bacterial components.
    • Antisera to S. mutans serotype g (strain OMZ-65) and serotype e (strain MT703) reacted with kidney glomeruli, with varying degrees of reducibility by bacterial antigens.

    Conclusions:

    • Certain Streptococcus mutans strains possess antigens that cross-react with human cardiac, skeletal muscle, and kidney tissues.
    • The specific bacterial components involved in cross-reactivity vary by strain and tissue.
    • These findings highlight the potential for oral bacteria to elicit autoimmune responses.