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Related Experiment Videos

[Experimental study of a gentamycin ointment].

E Z Kagan, V K Vasil'ev, M A Bykova

    Antibiotiki
    |March 1, 1978
    PubMed
    Summary

    A new 0.1% gentamicin ointment was developed using a vaseline and paraffin base. This formulation ensures prolonged gentamicin diffusion through the skin with no observed local irritation.

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    [Pharmacological evaluation of bicillin].

    Antibiotiki·2014

    Area of Science:

    • Pharmaceutical Technology
    • Dermatology
    • Pharmacokinetics

    Context:

    • Development of topical antimicrobial formulations is crucial for managing skin infections.
    • Optimizing drug delivery through the skin requires careful selection of ointment bases.
    • Gentamicin is a widely used antibiotic for bacterial skin infections.

    Purpose:

    • To develop and characterize a novel 0.1% gentamicin ointment.
    • To evaluate the pharmacokinetic profile of gentamicin diffusion through the skin.
    • To assess the local innocuousness and safety of the developed gentamicin ointment.

    Summary:

    • A 0.1% gentamicin ointment was successfully produced using a base of vaseline and paraffin (95:5).
    • Pharmacokinetic studies demonstrated sustained diffusion of gentamicin through the skin.
    • Histological examinations confirmed the absence of local irritation upon topical application.

    Impact:

    • This research provides a new, effective, and safe topical gentamicin formulation.
    • The developed ointment offers potential for prolonged antimicrobial activity in skin applications.
    • Findings support the use of this formulation in treating superficial skin infections.

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