Related Experiment Videos
Objective evaluation of dextromethorphan and glaucine as antitussive agents
British Journal of Clinical Pharmacology
|May 1, 1984
Summary
Glaucine and dextromethorphan reduced chronic cough frequency compared to placebo. Glaucine demonstrated a statistically significant reduction in coughs, indicating its potential as an effective cough suppressant.
Area of Science:
- Pharmacology
- Clinical Medicine
- Respiratory Medicine
Background:
- Chronic cough is a persistent respiratory symptom impacting quality of life.
- Limited effective treatments exist for chronic cough, necessitating research into novel therapeutic agents.
Purpose of the Study:
- To evaluate the efficacy and tolerability of glaucine and dextromethorphan in managing chronic cough.
- To compare the antitussive effects of glaucine and dextromethorphan against a placebo.
Main Methods:
- A single-dose, double-blind, placebo-controlled, cross-over study was conducted.
- Twenty-four inpatients with chronic cough received two of three treatments: placebo, glaucine 30 mg, or dextromethorphan 30 mg.
- Cough frequency was objectively measured using a cough recorder.
Main Results:
- Both glaucine and dextromethorphan reduced cough frequency compared to placebo.
- Glaucine showed a statistically significant reduction in coughs compared to placebo.
- Treatments were generally well-tolerated, with fewer side effects reported for glaucine than dextromethorphan.
Conclusions:
- Glaucine is a promising agent for reducing chronic cough frequency.
- Further research may explore glaucine's long-term efficacy and safety profile in cough management.