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Remodeling the estrogen receptor model.

J Gorski, W Welshons, D Sakai

    Molecular and Cellular Endocrinology
    |June 1, 1984
    PubMed
    Summary
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    The revised estrogen receptor model places receptors within the nucleus, whether bound to estrogen or not. Receptor binding to nuclear targets, even without estrogen, is key to hormone response.

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Cell Biology

    Background:

    • The estrogen receptor (ER) plays a crucial role in cellular responses to estrogen.
    • Previous models did not fully account for ER's subcellular localization and physical state.
    • New data necessitates a revision of the existing ER model.

    Purpose of the Study:

    • To revise the estrogen receptor model incorporating new data.
    • To elucidate the role of receptor localization and physical state in estrogenic responses.

    Main Methods:

    • Integration of new data on subcellular localization.
    • Analysis of physical characteristics of solubilized versus immobilized receptors.
    • Revision of the estrogen receptor model.

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    Main Results:

    • The revised model indicates estrogen receptors are present in the nuclear fraction, irrespective of estrogen binding.
    • Receptors exhibit behavior consistent with being immobilized or bound to nuclear components.
    • Estrogen-free receptor association with nuclear targets is identified as critical.

    Conclusions:

    • The nuclear localization and immobilized state of the estrogen receptor are central to its function.
    • The critical event in estrogenic hormone response involves the association of the unbound receptor with nuclear targets.
    • This revised model provides a more accurate framework for understanding estrogen receptor action.