Development of immune complex nephritis during treatment with the calcium channel-blocking agent nifedipine

Following multiple myocardial infarctions, a patient was treated with the calcium channel-blocking agent nifedipine. Within three months he had proteinuria of up to 460 mg/24 hours. Renal biopsy showed an immune complex glomerulonephritis. The presence of microfibrils was associated with the capillary basement membrane and mesangial changes.