Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A score for prescribing digoxin.

P W Nicholson, S M Dobbs, A P McGill

    British Heart Journal
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Physiological performance of common carp (Cyprinus carpio, L., 1758) exposed to a sublethal copper/zinc/cadmium mixture.

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·2020
    Same author

    Positive reinforcement targeting abstinence in substance misuse (PRAISe): Study protocol for a Cluster RCT & process evaluation of contingency management.

    Contemporary clinical trials·2018
    Same author

    Transdisciplinary synthesis for ecosystem science, policy and management: The Australian experience.

    The Science of the total environment·2015
    Same author

    Morphological and molecular variation in the least madtom Noturus hildebrandi (Siluriformes: Ictaluridae), a Mississippi Embayment endemic: evidence for a cryptic lineage in the Hatchie River.

    Journal of fish biology·2015
    Same author

    Psychiatric genetics.

    Recent progress in psychiatry·2014
    Same author

    Significantly higher frequency of Helicobacter suis in patients with idiopathic parkinsonism than in control patients.

    Alimentary pharmacology & therapeutics·2013
    Same journal

    Cardiac enlargement with bradycardia in recruits.

    British heart journal·2010
    Same journal

    Paravertebral block and the electrocardiogram in angina pectoris.

    British heart journal·2010
    Same journal

    Induced changes in the circulation in constrictive pericarditis.

    British heart journal·2010
    Same journal

    Angina pectoris with associated left paroxysmal ptosis.

    British heart journal·2010
    Same journal

    Myxoedema with pericardial effusion.

    British heart journal·2010
    Same journal

    Hypoxaemia tests in coronary disease.

    British heart journal·2010
    See all related articles

    A new method helps select adult digoxin maintenance doses using eight patient factors. This approach aims to improve therapeutic drug levels and patient outcomes compared to existing methods.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Internal Medicine

    Background:

    • Digoxin dosing requires careful consideration to maintain therapeutic serum concentrations.
    • Existing methods for digoxin dose selection may have limitations in accuracy and applicability.

    Purpose of the Study:

    • To develop and validate a simple, data-driven method for selecting adult digoxin maintenance doses.
    • To improve the predictability of achieving target serum digoxin concentrations.

    Main Methods:

    • A prescribing aid was developed using data from 129 adult patients on digoxin.
    • The aid incorporates eight readily available patient variables: inpatient/outpatient status, sex, age, weight, mobility, cardiac rhythm, serum creatinine, and diuretic use.

    Main Results:

    Related Experiment Videos

    • The method predicts that 72.3% of patients will achieve therapeutic serum digoxin concentrations.
    • An additional 6.5% are expected to be above and 21.2% below the therapeutic range.
    • This performance is anticipated to surpass that of other available prescribing aids.

    Conclusions:

    • The developed method offers a straightforward approach to digoxin maintenance dose selection.
    • Routine serum digoxin concentration monitoring is advised for dose adjustments, particularly increases, to optimize therapy.