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Small-bowel abnormalities in multiple sclerosis.

L S Lange, M Shiner

    Lancet (London, England)
    |December 18, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Multiple sclerosis (MS) patients show jejunal mucosal abnormalities, including inflammation and villous atrophy. Ultrastructural analysis revealed significant fine structural changes in the small intestine lining.

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    Area of Science:

    • Gastroenterology
    • Neurology
    • Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • The potential involvement of the gastrointestinal tract in MS pathogenesis remains an area of investigation.

    Purpose of the Study:

    • To investigate the histological and ultrastructural characteristics of the jejunal mucosa in patients with multiple sclerosis.

    Main Methods:

    • Jejunal biopsies were obtained from 12 patients with multiple sclerosis.
    • Histological, ultrastructural, and tissue immune techniques were employed for examination.

    Main Results:

    • Histology revealed normal mucosa in 7 patients, with inflammatory infiltration or villous atrophy in 5.

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  • Ultrastructural abnormalities were observed in 6 of 8 patients, including microvillous changes, increased lymphocytes and lysosomes, connective tissue thickening, and macrophages with electron-dense material.

    • Conclusions:

    • Jejunal mucosal abnormalities are present in a subset of multiple sclerosis patients.
    • These findings suggest potential gastrointestinal involvement in the pathophysiology of multiple sclerosis.