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Updated: Aug 19, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
[The morphogenetic potential of tumor cells]
Abstract:
The data on the induction of normalization of tumour cells in terms of their ability to be morphologically and functionally incorporated into normal tissues and organs are reviewed. Such a process, though usually connected with differentiation of tumour cells, is not identical to that. Two groups of data are considered--normalization of tumour cells under morphogenic factors of embryonal development and that under reparative regeneration factors. The ability of tumour cells to undergo normalization in the embryonic morphogenic field is quite evident; the general regularities of the process are stated, and main efforts are aimed at widening the spectrum of the tumours involved into normal embryogenesis. In experiments with reparative regeneration only preliminary results have been obtained.
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