Vasodilator mechanism of the intracerebral (non-sympathetic) adrenergic pathway

Stimulation of the intracerebral noradrenergic pathway causes a vasodilatation in the hypothalamus. We have investigated whether this vasodilatation is caused by a direct vascular innervation or whether it is secondary to an activation of hypothalamic neurons. Non-specific neuronal activation using glutamate increased the mean hypothalamic blood flow. Depression of neuronal activity using barbiturate reduced hypothalamic blood flow and blocked the glutamate and the intracerebral noradrenergic pathway-induced vasodilatation. These results suggest that stimulation of the intracerebral noradrenergic pathway increases hypothalamic neuronal activity which indirectly causes a vasodilatation.