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Methods of complex impedance measurements in biologic tissue
Critical Reviews in Biomedical Engineering
|January 1, 1984
Summary
Bioelectric impedance analysis offers insights into physiologic events but faces limitations. Advanced materials science techniques, measuring real and reactive components across frequencies, can overcome these challenges for better biologic system analysis.
Area of Science:
- Biophysics
- Materials Science
- Physiology
Background:
- Bioelectric impedance measurements are valuable for monitoring physiologic events.
- Current methods have limitations in defining current pathways and distinguishing volumetric vs. material property changes.
Purpose of the Study:
- To review advanced materials science techniques for bioimpedance analysis.
- To address limitations of current bioimpedance methods in complex biologic systems.
Main Methods:
- Utilizing materials science techniques measuring real and reactive impedance components over a wide frequency range.
- Employing various plotting and analytic techniques for data interpretation.
- Reviewing applications in cell suspensions and biologic tissues.
Main Results:
- Advanced techniques can overcome limitations of traditional bioimpedance analysis.
- Accurate measurement of the reactive component in conductive biologic systems is challenging.
- Safety considerations limit in vivo human applications to frequencies above 20 kHz.
Conclusions:
- Materials science approaches offer enhanced bioimpedance analysis capabilities.
- Further instrumentation development is needed for broader in vivo applications.
- These techniques show promise for studying cell suspensions and biologic tissues.