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Updated: May 22, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
[Allogeneic bone transplantation. Indications--preservation--results]
Deep-frozen preserved allografts are effective for bone defects, offering excellent results when used correctly. This method preserves autogenous bone for complex cases and shows comparable consolidation to autografts after 20 weeks.
Area of Science:
- Orthopedic Surgery
- Traumatology
- Biomaterials Science
Context:
- The University Department of Traumatology Freiburg i.Br. has utilized deep-frozen preserved allogenous bone grafts for 15 years.
- Standardized organization and services of the "bone bank" facilitate consistent graft availability.
- Established indications include complex fractures and acetabular defects in total hip replacements.
Purpose:
- To outline the established indications and contraindications for using deep-frozen preserved allogenous cancellous bone grafts.
- To highlight the benefits of allografts in managing osseous defects, particularly in polytraumatized patients.
- To compare the efficacy and consolidation times of allografts versus autografts.
Summary:
- Deep-frozen allogenous cancellous bone grafts are indicated for fresh fractures with osseous defects and acetabular defects, provided the recipient site is well-vascularized and infection-free.
- Absolute contraindications include open fractures and local infections.
- Excellent results are achieved when transplantation criteria are met, with comparable consolidation to autografts after approximately 20 weeks.
Impact:
- Allografts serve as a valuable resource, especially for polytraumatized patients, conserving autogenous bone for more challenging reconstructive needs.
- The technique offers a reliable solution for significant bone defects, improving patient outcomes in trauma care.
- The availability and efficacy of preserved allografts enhance surgical options in reconstructive traumatology.
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