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Organic acids in amniotic fluid.

T M Nicholls, R Hähnel, S P Wilkinson

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |March 1, 1978
    PubMed
    Summary
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    Researchers identified approximately 30 organic acids in human amniotic fluid, establishing a normal metabolic profile. This profile aids in detecting abnormal metabolic patterns for improved diagnostic capabilities.

    Area of Science:

    • Biochemistry
    • Metabolomics
    • Analytical Chemistry

    Background:

    • Human amniotic fluid contains a complex mixture of metabolites.
    • Understanding the metabolic profile is crucial for prenatal diagnostics.

    Purpose of the Study:

    • To characterize the organic acid composition of human amniotic fluid.
    • To establish a reference "normal" metabolic profile for organic acids.
    • To provide a basis for identifying abnormal metabolic patterns.

    Main Methods:

    • Gas chromatography coupled with mass spectrometry (GC-MS) was employed.
    • Analysis focused on the identification and quantification of organic acids.
    • A cohort was used to define the "normal" metabolic profile.

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    Main Results:

    • Approximately 30 distinct organic acids were identified in human amniotic fluid.
    • A comprehensive "normal" metabolic profile of these acids was established.
    • Variations from this profile can indicate metabolic abnormalities.

    Conclusions:

    • The established normal organic acid profile serves as a vital reference.
    • This profile facilitates the detection of metabolic disorders during prenatal development.
    • GC-MS is a powerful tool for amniotic fluid metabolomic analysis.