[Demonstration of the tick-borne encephalitis virus by a solid-phase immunoenzyme method in materials from natural...

Large-scale examinations of specimens from natural foci of tick-borne encephalitis (TBE) demonstrated that sensitivity of solid-phase enzyme immunoassay (EIA) in detecting TBE virus antigen was as high as that of the fluorescent antibody technique. The EIA takes less time and may be used for examinations of specimens after a preliminary passage in cell cultures. The EIA was also shown to be highly effective in the detection of TBE virus antigen in the cerebral tissue of patients post mortem and in the confirmation of the clinical diagnosis.