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Primary dapsone resistant leprosy in Nepal.

N M Samuel, S Samuel, J Loudon

    Indian Journal of Leprosy
    |October 1, 1984
    PubMed
    Summary
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    Primary dapsone resistance in leprosy is high, with 87% of tested patients showing resistance. This study highlights the urgent need for alternative leprosy treatments due to widespread drug resistance.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Dermatology

    Background:

    • Leprosy remains a significant global health challenge.
    • Dapsone has been a cornerstone of multidrug therapy for leprosy.
    • Emerging drug resistance threatens effective leprosy control.

    Purpose of the Study:

    • To evaluate the prevalence of primary dapsone resistance in leprosy patients.
    • To assess the susceptibility of leprosy bacilli to dapsone in a clinical setting.

    Main Methods:

    • Mouse foot pad testing was conducted on 15 patients with suspected dapsone resistance.
    • Patient histories regarding leprosy contact and demographics were collected.

    Main Results:

    • A high rate of primary dapsone resistance was observed, with 13 out of 15 patients (87%) exhibiting resistance.

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  • The study identified various patient backgrounds, including young children with infected mothers and individuals with no known leprosy contact.

    • Conclusions:

    • Primary dapsone resistance in leprosy is a significant clinical concern.
    • The findings underscore the need for updated diagnostic and therapeutic strategies for leprosy management.