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Updated: Aug 19, 2026

08:08
Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
Concentration-dependent effects of mycobacteria on the stimulation of murine T-cell clones
Abstract:
M. leprae produced concentration-dependent bimodal effects in cultures of M. leprae-immune lymphocytes. At low to intermediate concentrations, M. leprae and other species of mycobacteria stimulated lymphoproliferation of M. Leprae T-helper cell clones, whereas at high concentrations responses were reduced. Lymphokine production by M. leprae-immune T-cell hybridomas also showed bimodal responses to different concentrations of M. leprae. These results indicate that mycobacterial antigen may directly induce tolerance of responsing lymphocytes.

