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Diazepam in intractable sleepwalking: a pilot study.

W H Reid, E A Haffke, C C Chu

    The Hillside Journal of Clinical Psychiatry
    |January 1, 1984
    PubMed
    Summary
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    Nightly diazepam (10mg) effectively treated adult sleepwalking in some patients, with no serious side effects. This study supports diazepam as a potential treatment for intractable sleepwalking, though individual responses vary.

    Area of Science:

    • Neurology
    • Sleep Medicine
    • Pharmacology

    Background:

    • Sleepwalking (somnambulism) is a sleep disorder characterized by complex behaviors during sleep.
    • Intractable sleepwalking can significantly impact an individual's quality of life.
    • Previous case reports suggested potential benefits of benzodiazepine treatment.

    Purpose of the Study:

    • To evaluate the efficacy of diazepam in treating adult sleepwalking.
    • To assess the safety and tolerability of nightly diazepam administration for sleepwalking.

    Main Methods:

    • A double-blind, crossover study design was employed.
    • Participants received nightly diazepam (10mg) or placebo.
    • Patient-reported symptom alleviation and side effects were monitored.

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    Main Results:

    • Nightly diazepam (10mg) alleviated sleepwalking symptoms in a subset of adult participants.
    • Some individuals did not exhibit a significant response to diazepam.
    • No serious adverse effects or medication tolerance were observed during the study.

    Conclusions:

    • Diazepam demonstrates efficacy in treating adult sleepwalking for certain individuals.
    • The findings align with previous uncontrolled case reports.
    • Further research is warranted to explore other benzodiazepines for sleepwalking treatment.