Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serological markers in progressive systemic sclerosis: clinical correlations.

L J Catoggio, R M Bernstein, C M Black

    Annals of the Rheumatic Diseases
    |February 1, 1983
    PubMed
    Summary

    Autoantibodies are common in progressive systemic sclerosis (PSS). Anticentromere antibodies are specific to CREST syndrome and linked to milder disease, while anti-Scl-70 antibodies indicate a higher likelihood of lung involvement.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rationale and recommendations for improving early-stage oncology diagnosis, treatment, and access.

    Journal of medical economics·2026
    Same author

    Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma.

    Frontiers in oncology·2025
    Same author

    In vitro effects of macrophages on orthopaedic implant alloys and local release of metallic alloy components.

    The bone & joint journal·2020
    Same author

    Small Talk: Identifying communication problems in maltreated children.

    Child abuse & neglect·2017
    Same author

    A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis.

    AJNR. American journal of neuroradiology·2014
    Same author

    Multisociety Consensus Quality Improvement Guidelines for Intra-Arterial Catheter-Directed Treatment of Acute Ischemic Stroke: implications for neuroradiology and stroke centers.

    AJNR. American journal of neuroradiology·2013

    Area of Science:

    • Rheumatology
    • Immunology
    • Clinical Medicine

    Background:

    • Progressive systemic sclerosis (PSS) is an autoimmune disease characterized by widespread connective tissue damage.
    • Understanding the relationship between clinical manifestations and serological markers is crucial for diagnosis and prognosis.

    Purpose of the Study:

    • To investigate the association between clinical and serological findings in patients with progressive systemic sclerosis (PSS).
    • To determine the prevalence and specificity of autoantibodies, including anticentromere and anti-Scl-70, in different PSS subtypes.

    Main Methods:

    • Indirect immunofluorescence using HEp-2 cells to detect antinuclear antibodies (ANA).
    • Immunodiffusion assays to identify precipitating antibodies to nuclear and cytoplasmic antigens.

    Related Experiment Videos

  • Correlation of antibody findings with clinical features such as calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia (CREST), and diffuse disease.

    • Main Results:

    • Antinuclear antibodies (ANA) were detected in 95% of PSS patients.
    • Anticentromere antibodies were found in 50% of patients with CREST syndrome versus 7% with diffuse PSS.
    • Anti-Scl-70 antibodies were identified in 21% of patients and associated with a high frequency of lung involvement.
    • A combination of immunofluorescence and immunodiffusion detected characteristic PSS antibodies in 51% of patients.

    Conclusions:

    • Autoantibodies are highly prevalent in PSS, with varying specificities.
    • Anticentromere antibody is a specific marker for CREST syndrome and predicts a less severe disease course.
    • Anti-Scl-70 antibody is associated with increased risk of lung involvement in PSS patients.