Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progabide: a controlled trial in partial epilepsy.

M Dam, L Gram, A Philbert

    Epilepsia
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Secondary amputation after lower extremity free-flap reconstruction.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2023
    Same author

    The relationships between early lactation energy status indicators and endocrine fertility traits in dairy cows.

    Journal of dairy science·2022
    Same author

    Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization - proof-of-concept study.

    The Journal of hospital infection·2021
    Same author

    Genetic parameters for reproductive losses estimated from in-line milk progesterone profiles in Swedish dairy cattle.

    Journal of dairy science·2020
    Same author

    Corrigendum to "Genetic parameters of endocrine fertility traits based on in-line milk progesterone profiles in Swedish Red and Holstein dairy cows" (J. Dairy Sci. 102:11207-11216).

    Journal of dairy science·2020
    Same author

    Genetic parameters of endocrine fertility traits based on in-line milk progesterone profiles in Swedish Red and Holstein dairy cows.

    Journal of dairy science·2019
    Same journal

    Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

    Epilepsia·2026
    Same journal

    Outcome trajectories after pediatric epilepsy surgery vary by biopsychosocial phenotypes.

    Epilepsia·2026
    Same journal

    Comparative risk of epilepsy with SGLT2 inhibitors versus incretin-based therapies in type 2 diabetes.

    Epilepsia·2026
    Same journal

    Long-term mortality after status epilepticus: A 5-year analysis study.

    Epilepsia·2026
    Same journal

    The Epilepsy-Cog study: Methods to establish a harmonized study of late onset epilepsy in a metacohort of six population-based cohorts in the United States.

    Epilepsia·2026
    Same journal

    Systematic review and meta-analysis of lifestyle modification interventions and their impact on seizure reduction and quality of life.

    Epilepsia·2026
    See all related articles

    Progabide did not significantly reduce partial complex seizures in a randomized trial. However, a trend suggested fewer secondary generalized seizures, with mild, transient side effects comparable to placebo.

    Area of Science:

    • Neurology
    • Clinical Pharmacology

    Background:

    • Epilepsy management requires effective antiepileptic drugs.
    • Partial complex seizures present a therapeutic challenge.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Progabide (SL 76002) in treating partial complex seizures.
    • To compare Progabide against placebo in an add-on therapy setting.

    Main Methods:

    • Randomized, double-blind, crossover trial with 20 outpatients.
    • Progabide added to existing antiepileptic treatment at fixed doses.
    • Included an open-label therapy control period.

    Main Results:

    • No significant difference in partial seizure frequency between Progabide and placebo.

    Related Experiment Videos

  • A trend towards reduced secondary generalized seizure frequency with Progabide.
  • Progabide exhibited mild and transient side effects, similar to placebo.

    • Conclusions:

    • Progabide showed no significant efficacy for partial complex seizures in this trial.
    • A potential trend for reducing secondary generalized seizures warrants further investigation.
    • Progabide appears safe and well-tolerated as add-on therapy for epilepsy.