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Thyroid screening in the newborn: Utah experience.

B A Buehler, M J Gortatouski, G Scow

    Annals of Clinical and Laboratory Science
    |January 1, 1983
    PubMed
    Summary
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    Newborn screening in Utah identified 1 hypothyroid child per 3,800 births since 1979. Less than 1% of infants were falsely flagged, ensuring accurate diagnosis of congenital hypothyroidism.

    Area of Science:

    • Pediatrics
    • Endocrinology
    • Public Health

    Background:

    • Congenital hypothyroidism (CH) is a treatable condition requiring early diagnosis.
    • Newborn screening programs are crucial for identifying CH in infants.
    • The Utah State Department of Health Laboratory has a long-standing newborn screening program.

    Purpose of the Study:

    • To review the incidence and screening accuracy of congenital hypothyroidism in Utah newborns.
    • To evaluate the effectiveness of the established newborn screening protocol.

    Main Methods:

    • Analysis of screening data for 108,256 newborn infants from 1979 onwards.
    • Application of a defined normal range for serum thyroid hormone levels (8.0–26.0 µg/dL).
    • Calculation of incidence rates for diagnosed CH and false-positive results.

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    Main Results:

    • An incidence of 1 diagnosed hypothyroid case per 3,800 live births was observed.
    • Fewer than 1% of screened infants were initially identified as hypothyroid but later confirmed normal.
    • The screening protocol demonstrated high specificity.

    Conclusions:

    • The Utah newborn screening program effectively identifies congenital hypothyroidism.
    • The established screening parameters minimize false positives, ensuring efficient resource allocation.
    • Long-term newborn screening data supports the reliability of CH detection.