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Updated: Aug 14, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Promoting effect of biliverdin for liver cells initiated by aflatoxin B1
Abstract:
In this paper we have studied the participation of biliverdin, a bile pigment produced from hemoglobin catabolism, in a two-stage carcinogenesis model using hepatic cells in culture. The initiation was realised by a short term exposure to low doses of aflatoxin B1. The cells were then cultivated in the presence of biliverdin in the medium. We observed that biliverdin increased the rate and the efficiency of neoplastic transformation of cells. These results suggest that biliverdin may act as a promoting substance.
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