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Related Experiment Videos

Analgesic-induced asthma.

J P Seale

    The Medical Journal of Australia
    |June 11, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Aspirin and NSAID-sensitive asthma attacks are linked to inhibiting cyclo-oxygenase, not immune responses. This mechanism may involve altered arachidonic acid metabolism, affecting bronchoconstrictor and bronchodilator pathways.

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    Area of Science:

    • Pharmacology
    • Pulmonology
    • Immunology

    Background:

    • Aspirin-induced asthma affects 2-28% of asthma patients.
    • Incidence is similar in children and adults.
    • Immunological mechanisms are not considered likely causes.

    Purpose of the Study:

    • To explore the mechanism of analgesic-induced asthma.
    • To investigate the role of cyclo-oxygenase inhibition in aspirin-sensitive asthma.

    Main Methods:

    • Review of existing studies on aspirin and asthma.
    • Analysis of the cyclo-oxygenase pathway in relation to NSAID use.

    Main Results:

    • Non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting cyclo-oxygenase can trigger asthma attacks.

    Related Experiment Videos

  • Structural dissimilarity among NSAIDs makes immunological cross-reactivity unlikely.
  • The mechanism may involve altered arachidonic acid metabolism.

    • Conclusions:

    • Inhibition of cyclo-oxygenase by NSAIDs is a likely cause of bronchospasm in aspirin-sensitive asthma.
    • This may result from reduced bronchodilator cyclo-oxygenase products or increased bronchoconstrictor lipoxygenase products.