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Monocyte function in human neonates.

J D Berman, W D Johnson

    Infection and Immunity
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Newborn monocytes from cord blood show higher yields and comparable functional activities to adult monocytes. These neonatal immune cells are competent, demonstrating normal responses to Toxoplasma gondii.

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    Area of Science:

    • Immunology
    • Neonatal Biology
    • Cellular Biology

    Background:

    • Neonatal immune system development is crucial for infant health.
    • Understanding monocyte function in newborns is essential for assessing immune competence.

    Purpose of the Study:

    • To evaluate the functional and biochemical activities of monocytes from healthy newborns.
    • To compare neonatal monocyte characteristics with those of adult monocytes.

    Main Methods:

    • Isolation of monocytes from newborn cord blood and adult peripheral blood.
    • Quantification of monocyte yield, morphology, and enzymatic activities (lysozyme, peroxidase, 5'-nucleotidase).
    • Assessment of Fc and complement receptor activity, phagocytosis, and intracellular Toxoplasma gondii multiplication.

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    Main Results:

    • Newborn monocytes exhibited a 60% greater yield compared to adult monocytes.
    • Both newborn and adult monocytes showed similar patterns in enzyme activity changes during in vitro cultivation.
    • Neonatal monocytes effectively ingested and supported intracellular multiplication of Toxoplasma gondii, with comparable inhibition observed in both groups.

    Conclusions:

    • Monocytes from healthy newborns are functionally competent.
    • Neonatal monocytes possess comparable cellular activities to adult monocytes, including responses to pathogens and immune modulators.