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Related Experiment Videos

Erythrocyte filtrability measurement by the initial flow rate method.

M Hanss

    Biorheology
    |January 1, 1983
    PubMed
    Summary
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    A novel filtration method accurately measures red blood cell (RBC) filterability using an intrinsic filtration index (IF). This technique is rapid, reproducible, and insensitive to common experimental interferences.

    Area of Science:

    • Hematology
    • Biomedical Engineering
    • Biophysics

    Background:

    • Red blood cell (RBC) deformability is crucial for microcirculation.
    • Assessing RBC filterability is vital for diagnosing various hematological disorders.
    • Existing methods can be affected by filter clogging and sedimentation.

    Purpose of the Study:

    • To introduce a new, rapid filtration technique for quantifying RBC filterability.
    • To establish a reliable filtration index (IF) that is independent of filter and medium properties.
    • To evaluate the reproducibility and influencing factors of the new method.

    Main Methods:

    • A diluted RBC suspension was filtered through 5 µm Nucleopore filters.
    • Initial filtration rates were measured electronically within seconds.

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  • A filtration index (IF) was calculated, representing intrinsic RBC filterability.

    • Main Results:

    • The method is insensitive to filter plugging and sedimentation effects.
    • The filtration index (IF) is largely independent of filter conductance and medium viscosity.
    • The relative uncertainty in IF measurement was approximately +/- 10% with the described procedure.
    • Factors influencing reproducibility, including RBC washing and storage, were assessed.

    Conclusions:

    • The described filtration technique provides a robust and reproducible measure of RBC filterability.
    • The filtration index (IF) is an intrinsic property of RBCs, valuable for clinical and research applications.
    • This method offers a sensitive and reliable tool for evaluating red blood cell function.