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[Incidence of posthepatic sequelae of acute viral hepatitis C]
Insights
Long-term prognosis for non-A/non-B hepatitis C virus infection is now clearer. Most infected women recovered within three years, but some developed chronic hepatitis, highlighting the need for further study.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Context:
- Hepatitis C virus (HCV) was previously categorized under non-A/non-B hepatitis.
- Limited data existed on the long-term outcomes of transfusion-independent non-A/non-B hepatitis.
- This study focused on women infected via contaminated anti-D-globulin.
Purpose:
- To investigate the post-hepatitic sequelae of hepatitis C virus infection.
- To provide initial evidence on the long-term prognosis of hepatitis C.
- To establish control groups for long-term observation of hepatitis C outcomes.
Summary:
- 115 women exposed to HCV via contaminated anti-D-globulin were observed.
- 49.5% (57/115) developed hepatitis C.
- After 3 years: 68.4% (39/57) cured, 12.3% (7/57) residual hepatitis, 17.5% (10/57) chronic persistent hepatitis, 1.75% (1/57) chronic active hepatitis.
Impact:
- Provides crucial early data on hepatitis C prognosis.
- Informs understanding of HCV sequelae in transfusion-independent cases.
- Contributes to the long-term epidemiological study of hepatitis C in the GDR.
Abstract:
There are not yet any ascertained results concerning the prognosis of the non-A/non-B hepatitis not depending on transfusion. In an identical source of infection meanwhile several working teams in the GDR by means of long-term observations for three years control groups of women able to propagate who were incubated by a hepatitis C-virus (of the non-A/non-B group of the hepatotropic viruses), so that first evidence on posthepatitic sequelae after hepatitis C is possible. Of 115 women who were treated with anti-D-globulin contaminated with C virus 57 women fell ill (= 49.5%). Of them 39 patients (3 68.4%) were cured after 3 years, 7 patients (6 12.3%) showed the signs of a residual hepatitis, 10 patients (3 17.5%) showed a chronically persisting and 1 patient (= 1.75%) a chronically active hepatitis. The results presented are compared to those of other working teams of our country.