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Neuroangiography with iohexol.

R N Bryan, S L Miller, J O Roehm

    AJNR. American Journal of Neuroradiology
    |May 1, 1983
    PubMed
    Summary
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    Iohexol, a new nonionic contrast agent, showed reduced pain and fewer motion artifacts in neuroangiography compared to older ionic agents. It appears to be a superior option for cerebral angiography and arch aortography.

    Area of Science:

    • Radiology
    • Medical Imaging
    • Pharmacology

    Background:

    • Nonionic, water-soluble contrast agents offer potential advantages over ionic agents.
    • Iohexol is a novel agent undergoing clinical evaluation.
    • Current ionic contrast agents like meglumine iothalamate and sodium meglumine diatrizoate are widely used but can cause adverse effects.

    Purpose of the Study:

    • To compare the safety and efficacy of iohexol with existing ionic contrast agents.
    • To evaluate iohexol's performance in selective cerebral angiography and arch aortography.
    • To assess patient-reported pain, hemodynamic changes, and image quality.

    Main Methods:

    • Double-blind, parallel clinical trials.
    • Comparison of iohexol versus meglumine iothalamate for cerebral angiography (60 patients).

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  • Comparison of iohexol versus sodium meglumine diatrizoate for arch aortography (40 patients).

    • Main Results:

    • Iohexol demonstrated significantly less patient discomfort (pain) compared to both ionic agents.
    • No significant differences in heart rate, blood pressure, or ECG changes were observed between iohexol and ionic agents.
    • Transient tachycardia and hypotension occurred less frequently with iohexol after arch aortography.
    • Comparable film quality was achieved, with iohexol showing reduced motion artifacts.
    • No significant complications were reported for any of the contrast agents.

    Conclusions:

    • Iohexol is a safe and effective nonionic contrast agent for neuroangiography.
    • Iohexol offers improved patient comfort and reduced motion artifacts compared to meglumine iothalamate and sodium meglumine diatrizoate.
    • Iohexol represents a superior alternative to current ionic neuroangiographic contrast agents.