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[Biological rhythms of thyrotropin secretion]
Annales De Medecine Interne
|January 1, 1983
Summary
Thyroid-stimulating hormone (TSH) secretion follows a daily rhythm, influenced by sleep, nutrition, and neurotransmitters like serotonin. This circadian pattern is crucial for understanding thyroid function regulation.
Area of Science:
- Endocrinology
- Chronobiology
- Neuroendocrinology
Background:
- Thyroid-stimulating hormone (TSH) secretion exhibits a well-established circadian rhythm.
- This rhythm is characterized by a 24-hour periodicity with a pre-sleep acrophase.
- External synchronizers, such as the sleep-waking cycle, modulate this TSH rhythm.
Purpose of the Study:
- To explore the factors influencing the circadian rhythm of TSH secretion.
- To investigate the roles of neurotransmitters, hormones, and physiological states in TSH rhythmicity.
Main Methods:
- Review of existing literature on TSH secretion patterns.
- Analysis of the influence of sleep, nutritional status, neurotransmitters (serotonin, dopamine), neuropeptides (TRH, somatostatin), thyroid hormones, sex hormones, and glucocorticoids on TSH rhythm.
Main Results:
- Sleep onset negatively impacts the nycthemeral TSH peak.
- Short-term starvation can shift the acrophase time.
- Serotonin is implicated in the TSH nadir, while dopamine is not directly involved in the circadian pattern.
- Thyroid hormones, sex hormones, and glucocorticoids primarily modulate mean TSH levels rather than circadian variations.
Conclusions:
- The circadian TSH rhythm is a complex process influenced by multiple endogenous and environmental factors.
- Neurotransmitters and neuropeptides play significant roles in mediating TSH rhythmicity.
- Further research is needed to fully elucidate the physiological influence of certain factors like glucocorticoids.