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Metoclopramide in gastrointestinal radiology
Journal of the Canadian Association of Radiologists
|March 1, 1978
Summary
Metoclopramide effectively reduces gastric emptying and small bowel transit times in patients. This gastrointestinal drug is safe, with negligible side effects, and aids in diagnostic radiology procedures.
Area of Science:
- Gastroenterology
- Radiology
- Pharmacology
Background:
- Metoclopramide has been used in Europe since the late 1960s for gastrointestinal motility disorders.
- Its application in North America and diagnostic radiology is less familiar.
Purpose of the Study:
- To evaluate the efficacy of intramuscular metoclopramide in altering gastric emptying and small bowel transit times.
- To assess the safety profile of metoclopramide in patients undergoing diagnostic radiology procedures.
Main Methods:
- A comparative study involving a control group (103 patients) and a study group (86 patients) receiving intramuscular metoclopramide.
- Assessment of gastric emptying time and small bowel transit time.
Main Results:
- Intramuscular metoclopramide significantly reduced gastric emptying time and small bowel transit time.
- Side effects were negligible in 125 patients.
- The drug proved useful in managing gastric stasis, differentiating obstruction from motility disorders, and in fluoroscopy of the terminal ileum and duodenal intubation.
Conclusions:
- Metoclopramide is an effective and safe agent for accelerating gastrointestinal transit.
- Its utility extends to specific diagnostic radiology applications, enhancing diagnostic capabilities.