Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Influence of mast cells on thyroid function.

A C Bianco, M T Nunes, C R Douglas

    Endocrinologia Experimentalis
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.

    Journal of endocrinological investigation·2021
    Same author

    Molecular basis of growth hormone daily mRNA and protein synthesis in rats.

    Life sciences·2018
    Same author

    Novel aspects of T<sub>3</sub> actions on GH and TSH synthesis and secretion: physiological implications.

    Journal of molecular endocrinology·2017
    Same author

    3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice.

    Acta physiologica (Oxford, England)·2016
    Same author

    Carbapenem-resistant Enterobacteriaceae on a cardiac surgery intensive care unit: successful measures for infection control.

    The Journal of hospital infection·2016
    Same author

    Elasticity in portion selection is predicted by severity of anorexia and food type in adolescents.

    Appetite·2016
    Same journal

    Endocrine parameters in acne vulgaris.

    Endocrinologia experimentalis·1990
    Same journal

    Inhibitory and stimulatory action of porcine follicular fluid on FSH-induced 125I-hCG specific binding in rat granulosa cells.

    Endocrinologia experimentalis·1990
    Same journal

    Effects of thyroid hormone, TRH and TSH on pro-TRH concentrations in various organs of rats.

    Endocrinologia experimentalis·1990
    Same journal

    The influence of PRL, LH alone and in combination upon progesterone secretion by porcine luteal cells in aggregate culture.

    Endocrinologia experimentalis·1990
    Same journal

    Nonsteroid antiandrogen inhibiting effect on testosterone metabolism in rat prostate and liver.

    Endocrinologia experimentalis·1990
    Same journal

    Nuclear binding of thyroid hormones and activity of malic enzyme and ornithine decarboxylase in rat liver during postnatal development.

    Endocrinologia experimentalis·1990
    See all related articles

    Thyroid gland function involves mast cells. Mast cell stabilizers partially blocked thyroid-stimulating hormone (TSH) actions, while mast cell disruptors increased thyroid hormone levels and TSH secretion.

    Area of Science:

    • Endocrinology
    • Immunology
    • Cell Biology

    Background:

    • Mast cells are immune cells with poorly understood roles in endocrine regulation.
    • Thyroid hormone homeostasis is primarily regulated by the hypothalamus-pituitary-thyroid axis.

    Purpose of the Study:

    • To investigate the role of mast cells in thyroid gland function and the hypothalamus-pituitary system.
    • To determine if mast cells modulate the effects of thyroid-stimulating hormone (TSH).

    Main Methods:

    • Administration of mast cell stabilizer (disodium cromoglycate) and mast cell disruptor (compound BW48-80) in rats.
    • Measurement of serum thyroid hormones (T4, T3), TSH, radioiodine uptake, and protein-bound iodine (PB131I).
    • Evaluation of mast cell involvement in TSH action and TRH/TSH secretion.

    Related Experiment Videos

    Main Results:

    • Disodium cromoglycate partially inhibited TSH effects on the thyroid gland.
    • BW48-80 administration increased T4, T3, radioiodine uptake, PB131I, and TSH serum concentrations.
    • Pre-treatment with disodium cromoglycate prevented BW48-80-induced alterations and TSH elevation.

    Conclusions:

    • Thyroidal mast cells act as intermediaries in TSH actions on the thyroid gland.
    • Mast cells actively participate in the regulation of thyrotropin-releasing hormone (TRH) and/or TSH secretion.
    • Mast cell modulation significantly impacts thyroid hormone levels and thyroid axis regulation.