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Related Experiment Videos

Choroid plexus papilloma. Light and electron microscopic study.

N Nakashima, K Goto, K Tsukidate

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Choroid plexus papilloma (CPP) cells exhibit unique microvilli and granules. Interstitial cells interact with CPP cells, and both cell types show phagocytic activity in culture.

    Area of Science:

    • Neurosurgery
    • Pathology
    • Cell Biology

    Background:

    • Choroid plexus papillomas (CPPs) are rare tumors originating from the choroid plexus epithelium.
    • Understanding the ultrastructural characteristics of CPPs is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the ultrastructural features of choroid plexus papilloma (CPP) cells and their associated interstitial cells.
    • To examine the cellular interactions and surface characteristics of CPPs using advanced microscopy techniques.

    Main Methods:

    • Surgically excised CPP tissues (7 cases) and cultivated cells were analyzed using light and electron microscopy.
    • Ruthenium red staining was employed to visualize cell surface structures.
    • Phagocytic activity was assessed in cultured CPP and interstitial cells after Latex treatment.

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    Main Results:

    • CPP cells displayed numerous microvillous processes with balloon-like features, lysosomes with haemosiderin, and dense granules (150-300 nm).
    • Interstitial cells with dense cytoplasm extended processes, interacting with CPP basal plasmalemma and occasionally breaching the basal lamina.
    • Ruthenium red staining highlighted positive surface reactions on CPP cells, microvilli, and cilia. Cultured CPP and interstitial cells demonstrated phagocytic activity.

    Conclusions:

    • CPP cells possess distinct ultrastructural features, including specialized microvilli and granules.
    • Interstitial cells play a role in the tumor microenvironment, interacting with CPP cells and the basal lamina.
    • The observed phagocytic activity suggests a dynamic cellular interaction within CPPs and their surrounding environment.