Localization of [3H]N-propylnorapomorphine binding in mouse striatum

The anatomic localization of specific striatal [3H]N-propylnorapomorphine ( [3H]PNA) binding was determined in male C57BL/6J mice. Striatal [3H]PNA binding was high affinity and sensitive to guanine nucleotides. Frontal cortical ablation did not alter striatal [3H]PNA binding, but reduced [3H]spiperone binding by 36%. Kainic acid reduced and 6-hydroxydopamine elevated [3H]PNA binding. A combined frontal cortical ablation and striatal kainic acid lesion was similar to that of kainate alone. These data are consistent with a localization of [3H]PNA binding sites on neurons intrinsic to the mouse striatum.