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Hormones and human milk.

D Gupta

    Endocrinologia Experimentalis
    |October 1, 1983
    PubMed
    Summary
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    Hormone levels in breast milk are generally safe for newborns. However, high levels of luteinizing hormone-releasing hormone (LH-RH) in milk warrant further investigation into potential effects on infant hormone development.

    Area of Science:

    • Endocrinology
    • Neonatal Physiology
    • Lactational Physiology

    Background:

    • Hormones are present in breast milk, raising concerns for neonatal health.
    • Previous studies suggested steroid hormone levels in milk are not a concern for infants.
    • Passive diffusion and active mechanisms contribute to hormone transfer from blood to milk.

    Purpose of the Study:

    • To evaluate the safety of hormone transfer into breast milk for neonates.
    • To investigate the implications of newly discovered high levels of LH-RH in milk.
    • To determine if elevated milk LH-RH impacts neonatal luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels.

    Main Methods:

    • Monitoring of hormone levels in breast milk post-lactogenesis.
    • Comparison of hormone concentrations in milk versus maternal blood.
    Keywords:
    Adrenal Cortex Hormones--analysisBiologyEndocrine SystemEstrogens--analysisFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHormonesHuman MilkJaundiceLactationLuteinizing Hormone--analysisMaternal PhysiologyOral ContraceptivesPhysiologyPituitary GlandPituitary Hormone Releasing HormonesPituitary HormonesProgestational HormonesProgesterone--analysisProlactin--analysis

    Related Experiment Videos

  • Assessment of neonatal LH and FSH levels in relation to milk LH-RH concentration.

    • Main Results:

    • Steroid hormone levels in milk were found to be within safe limits for neonates.
    • Luteinizing hormone-releasing hormone (LH-RH) was detected in milk at concentrations significantly exceeding those in blood.
    • A potential for disproportionately high LH and FSH levels in neonates was identified.

    Conclusions:

    • While most hormones in milk pose no significant risk, elevated LH-RH requires careful consideration.
    • Further examination of neonates is recommended to assess the impact of high milk LH-RH on the hypothalamic-pituitary-gonadal axis.
    • The findings highlight the need for vigilance regarding specific hormone concentrations in breast milk and their potential endocrine effects on infants.