[Blood and tissue levels of mitomycin C after intravesical instillation]

Local mitomycin C (MMC) bladder instillation immediately after transurethral resection of superficial transitional cell carcinoma of the bladder caused an MMC serum concentration up to 24.5 ng/ml of an average. Neither bladder perforation by TUR nor vesicorenal reflux are contraindications for local instillations MMC. Systemic side effects are not to be expected. The highest MMC concentrations were found in the cancer tissue. There were measurable concentrations of MMC down to the adventitia. The indication for immediate postoperative local MMC-chemotherapy is discussed.