Effects of electrical stimulation of the nucleus tractus solitarius on self-stimulation behavior

The electrical stimulation of the nucleus tractus solitarius (NTS) produced profound suppression of self-stimulation (ICSS) in cats. This effect depended on the sequence and side of NTS stimulation, as well as on the stimulus parameters and locus of self-stimulation. The suppressive effect of NTS stimulation on ICSS was not abolished by ipsilateral vagotomy, thus the vagal bradycardia probably is not involved in the suppression of ICSS.