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[Relationship between radiotherapy and tumor immunity in hosts]
Gan No Rinsho. Japan Journal of Cancer Clinics
|October 1, 1983
Summary
Less-fractionated preoperative irradiation enhances anti-tumor immunity in advanced cancers. This method boosts immune cell infiltration and activity, improving therapeutic outcomes for breast and stomach cancers.
Area of Science:
- Oncology
- Immunology
- Radiotherapy
Context:
- Preoperative irradiation is debated for therapeutic efficacy.
- Advanced breast and stomach cancers present treatment challenges.
Purpose:
- To evaluate the therapeutic effects of less-fractionated preoperative irradiation.
- To investigate the impact of this method on anti-tumor immunity.
Summary:
- A less-fractionated, high-dose preoperative irradiation technique was employed for advanced breast and stomach cancers.
- This method enhanced cancer cell antigenicity and inhibited immune suppression.
- Histopathological analysis revealed significant infiltration of immune cells (neutrophils, lymphocytes, macrophages, plasma cells) into tumor nests.
- Abscopal effects were observed in some cases.
- Peripheral lymphocyte counts, T cell and B cell activity, and blastoid formation rates increased post-irradiation.
- Immune skin test reactivity was also enhanced.
Impact:
- Demonstrates favorable results for advanced cancers using a novel irradiation strategy.
- Suggests a potential to enhance the host's immune response against tumors.
- Highlights the immunomodulatory effects of less-fractionated radiotherapy.