Genetic control of the murine IgM plaque-forming cell response to type III pneumococcal polysaccharide

The direct 5-day plaque-forming cell response of different inbred mouse strains to pneumococcal polysaccharide type III (SSS-III) varied from more than 10,000 per spleen, in BALB/c mice, to less than 2000 in C57BL mice. Responses of Igh congenic and recombinant inbred lines bearing different combinations of BALB/c and C57BL genes indicate that two or more gene loci are involved in controlling high or low responses. At least one is in the Igh-V region since BALB/c, BAB-14, and CB-8 KN mice (Igh-Va) had two to four times higher responses than CB-20 and CB-16 KN mice (Igh-Vb). Other gene loci must be involved, but nothing can be said about them at present.