[Acute kidney failure and its treatment using hemodialysis]

Commonly the pathogenesis of acute renal failure (ARF) in the first place takes into consideration acute circulatory and acute toxic nephropathies. But disturbances in humoral regulations are important as well. Compensatory-adaptional reactions of the kidney answering the tubular lesion are causing increasing serum levels of renin, serotonin and histamin accompanied by a consecutive decrease of the diaminoxidase-activity, the latter as the hormone inactivating histamin. The results obtained form trials due to the dynamic behaviour of serotonin, histamin and diaminoxidase in the serum and urine respectively of 17 healthy persons (control), of 17 women with an ARF after abortation and of 5 patients with ARF from complications during pregnancy are reported. Rational managment of ARF should purchase an improvement in renal perfusion, the correction of metabolic deviation--among others--an increase of the diaminoxidase-activity.