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Modern quantitative acid-base chemistry.

P A Stewart

    Canadian Journal of Physiology and Pharmacology
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Computers now enable quantitative analysis of hydrogen ion dynamics in biological systems. This approach revolutionizes understanding and control of acid-base balance by distinguishing independent and dependent variables.

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    Area of Science:

    • Physiological chemistry
    • Biophysics
    • Systems biology

    Background:

    • Quantitative analysis of ionic solutions was historically limited by complex calculations.
    • Advancements in computing power have removed these previous limitations.

    Purpose of the Study:

    • To present a quantitative approach to understanding hydrogen ion behavior in living systems.
    • To outline the implications of this new quantitative framework for acid-base balance.

    Main Methods:

    • Distinguishing between independent variables (pCO2, net strong ion charge, total weak acid) and dependent variables ([HCO3-], [HA], [A-], [CO3(2-)], [OH-], [H+]).
    • Utilizing defining equations to calculate dependent variables from independent variables.
    • Applying quantitative analysis to understand whole-body acid-base balance and inter-body fluid interactions.

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    Main Results:

    • Hydrogen ion concentration is determined solely by changes in independent variables, not by movement between solutions.
    • A quantitative framework for understanding whole-body acid-base balance based on three independent variables and their physiological regulation.
    • Identification of strong ion movements across membranes as the primary mode of interaction between body fluids.

    Conclusions:

    • This quantitative approach offers a revolutionary method for predicting and controlling hydrogen ion behavior in biological systems.
    • Existing models of ion transport across membranes may require revision based on this analysis.
    • A comprehensive understanding of acid-base balance is achievable through quantitative analysis of independent physiological variables.