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Plasma discolouration due to sun-tanning aids
Vox Sanguinis
|January 1, 1984
Summary
New sun-tan capsules containing canthaxanthin can turn plasma orange for weeks. This discoloration can mask signs of red blood cell damage (hemolysis) in blood samples.
Area of Science:
- Biochemistry
- Hematology
- Clinical Pathology
Background:
- Canthaxanthin, a carotenoid derivative, is used in supplements for skin tanning.
- Plasma discoloration can interfere with laboratory testing.
- Hemolysis is the breakdown of red blood cells, a critical indicator in blood analysis.
Purpose of the Study:
- To investigate the effect of canthaxanthin-containing sun-tan capsules on plasma appearance.
- To determine the duration of plasma discoloration after capsule ingestion.
- To assess the potential of this discoloration to mask hemolysis in blood samples.
Main Methods:
- Observational analysis of plasma from blood donations.
- Tracking of plasma color changes in relation to capsule consumption.
- Evaluation of potential interference with hemolysis detection methods.
Main Results:
- Ingestion of 'Orobronze' capsules containing canthaxanthin caused noticeable orange discoloration of plasma.
- Plasma discoloration was observed in blood donations as early as 4 days after starting the capsules.
- The orange hue persisted for 4 weeks after cessation of capsule use, masking underlying hemolysis.
Conclusions:
- Canthaxanthin from sun-tan capsules causes prolonged plasma discoloration.
- This discoloration poses a diagnostic challenge by masking hemolysis in blood samples.
- Healthcare professionals should be aware of canthaxanthin use to avoid misinterpretation of blood test results.