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Long-term reversible contraception with levonorgestrel-releasing Silastic rods
American Journal of Obstetrics and Gynecology
|April 1, 1984
Summary
New levonorgestrel-releasing rods offer a reversible contraception alternative to capsules. This study found rods provide similar bleeding patterns, with higher levonorgestrel levels and fewer progesterone irregularities, suggesting they could replace capsules.
Area of Science:
- Reproductive Endocrinology
- Contraception
- Pharmacokinetics
Background:
- Subcutaneous levonorgestrel implants are effective reversible contraceptives for up to 5 years.
- Current levonorgestrel capsules require six 3 cm units for adequate serum levels.
- New Silastic rods offer potential manufacturing, insertion, and removal advantages.
Purpose of the Study:
- To compare the clinical and metabolic effects of levonorgestrel capsules versus rods.
- To evaluate bleeding patterns and serum hormone levels with both contraceptive systems.
- To determine the potential of levonorgestrel rods as a replacement for capsules.
Main Methods:
- A comparative study involving 23 women using either six levonorgestrel capsules (n=11) or two levonorgestrel rods (n=12).
- Serum levonorgestrel, lipid, and lipoprotein levels were measured pre-insertion and at 1, 6, 12, 18, and 24 months.
- Progesterone levels were assessed to identify cycles with elevated progesterone.
Main Results:
- Both systems showed similar bleeding patterns.
- Levonorgestrel rod users exhibited slightly higher serum levonorgestrel levels.
- Rod users had a lower incidence of cycles with elevated progesterone levels compared to capsule users.
Conclusions:
- Levonorgestrel rods demonstrate comparable efficacy and safety to capsules for long-term reversible contraception.
- The rod system may offer improved pharmacokinetic profiles and hormonal regulation.
- Levonorgestrel rods are a viable alternative to capsules, potentially improving user convenience and contraceptive outcomes.
Keywords:
BleedingBlood PressureContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive Implants--administraction and dosageContraceptive Implants--side effectsContraceptive Methods--administraction and dosageContraceptive Methods--side effectsExaminations And DiagnosesFamily PlanningHematocritHemoglobin LevelLaboratory Examinations And DiagnosesLaboratory ProceduresLevonorgestrelLipid Metabolic EffectsMetrorrhagiaReproductive Control Agents