[Effect of somatocrinin 1-40 (hpGRF-40) on human prolactinoma]

Growth Hormone-Releasing 1-40, from a human pancreatic tumor (hpGRF-40), stimulates adenylate cyclase activity of a subcellular preparation enriched in plasma membranes from a human prolactin-secreting pituitary adenoma. hpGRF-40 and VIP have 9 common residues. Nevertheless, the effects on adenylate cyclase are additive, suggesting the existence of specific receptors to hpGRF-40 in human prolactinoma.